Протеин, който прави обратими симптомите на Алцхаймер при мишки, откри екип от учени от Университета на Глазгоу, Великобритания, и Хонконгския университет за наука и технологии.
Изследователите определят своето откритие като абсолютен пробив и се надяват, че много скоро то ще може да се прилага и при хора. Новите данни отварят път към създаването на лечение на болестта, която нарушава способностите за мислене и запаметяване и води до загуба на паметта.
„Към момента медицинският свят все още не разполага с ефективно лечение на болестта на Алцхаймер, която е най-разпространената форма на деменция“, заяви ръководителят на екипа в Глазгоу проф. Еди Лю.
Прогнозата на учените е, че в резултат на застаряването на населението само след 14 години броят на болните от Алцхаймер в света ще достигне 65 милиона души.
Изследователите са направили поредица от опити с мишки, които са били отгледани по специален начин, който да да провокира развитието на болестта с напредването на възрастта. В процеса на работа те открили протеин – IL-33, който е в състояние да направи напълно обратимо отслабването на когнитивните функции.
Алцхаймер е прогресивно заболяване, чиито симптоми постепенно се изострят и увреждат все повече мозъчни зони.
„Инжектирането на протеина на мишки, развили заболяване, подобно на Алцхаймер, води до подобряване на когнитивните им функции“, обясни проф. Лю и допълни, че протеинът IL-33 подтиква имунните клетки в мозъка да атакуват характерните за Алцхаймер амилоидни плаки, като понижава броя и размера им.
„От друга страна протеинът спира възпалителните процеси, водещи до образуването на тези плаки“, допълни проф. Лю.
„Подобно откритие е много вълнуващо, но нека не бързаме да затаяваме дъх, защото практиката е показала, че са правени много фалшиви пробиви. Категоричната радост ще оставим за времето след строгите клинични тестове, които предстоят. Надяваме се резултатите да са такива, каквито очакваме“, каза още Лю.
Няколко по-ранни изследвания доказаха, че в мозъка на засегнати от Алцхаймер, има по-малко протеин IL-33 в сравнение с този при здрави хора.
Професор Еди Лю е старши научен сътрудник и професор по имунология в Университета на Глазгоу. Той е основател и директор на Biomedical Research Centre към Университета.
Източник: 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